What is Subutex?

The Subutex brand was discontinued in 2011, but the word is used to describe buprenorphine-only medication, as opposed to Suboxone which also contains naloxone for a safeguard. 

Both Subutex and Suboxone treat opioid addiction by keeping cravings and withdrawal symptoms manageable.

Subutex vs. Suboxone

Both Subutex and Suboxone have the same active ingredient — buprenorphine. But, Suboxone has an additional medication called naloxone that isn’t found in Subutex. 

Naloxone doesn’t impact the function of Suboxone unless it is abused.  If Suboxone is taken in excess or injected, the Naloxone can send a person into withdrawal instead of giving off a high and protects against overdose death. Subutex doesn’t have this safeguard.

Suboxone is safer than Subutex (buprenorphine-only). 

CompareSuboxoneSubutex
IngredientsBuprenorphine + NaloxoneBuprenorphine
Includes Safeguard Against AbuseYesNo
DeliverySublingual film under tongueSublingual tablet under tongue or monthly injection
Brand NamesSuboxone, Zubsolv, genericSubutex (discontinued), Sublocade (monthly injection), Belbuca, generic
Most Common Uses

Outpatient treatment / at-home prescription

For opioid detox & ongoing maintenance 

Inpatient treatment

For opioid detox & maintenance usually only if pregnant or Naloxone allergies

Subutex for Detox

Some addiction treatment providers prescribe Subutex (buprenorphine only) for the first days of opioid detox, then switch patients to Suboxone (buprenorphine + naloxone). 

The idea is to reduce the risk of precipitated withdrawal by not including naloxone. However, both Subutex and Suboxone cause precipitated withdrawals when induction dosages are not timed correctly. Working with a doctor experienced in opioid detox is the best way to avoid precipitated withdrawals.  Suboxone is the safer medication for outpatient use. 

Why Was Subutex Brand Discontinued?

Subutex was developed by the same manufacturer as Suboxone, now known as Indivior. Indivior cited safer alternatives as the reason for the discontinuation of Subutex in 2011. 

Generic buprenorphine-only medications are still used in specific situations like inpatient settings or during pregnancy.  But, Suboxone is safer and therefore a better option for most patients, especially for at-home use.

What Does Subutex Look Like?

Subutex brand tablets don’t exist anymore, but several manufacturers make buprenorphine-only tablets in 2mg and 8mg doses.

Buprenorphine-Only Tablets

While they may look like pills, buprenorphine is taken as tablets that dissolve under your tongue. 

Subutex Side Effects

The medication in Subutex (buprenorphine) is well-tolerated. 

The most common side effect reported by Symetria patients is constipation. Over-the-counter laxatives, fiber supplements or diet changes can help.

Less Common Side Effects of Subutex

Precipitated Withdrawal

Precipitated withdrawals are opioid withdrawal symptoms that hit patients suddenly after taking an anti-craving medication like Subutex too soon.

Symptoms of precipitated withdrawals can be severe and include diarrhea, headache, vomiting, anxiety, runny nose, body aches and chills.

If your initial dose of Subutex (buprenorphine) is taken at a clinic that’s experienced with opioid withdrawal, the risk of precipitated withdrawal is low and can be treated. Subutex should only be started when already in a state of withdrawal.

Subutex Abuse

Subutex (buprenorphine) has a ceiling effect that limits the euphoria and risk of overdose compared to full opioids like heroin or morphine. Patients with an opioid tolerance aren’t likely to feel “high” with Subutex and taking more Subutex does not give more euphoria. 

Buprenorphine Ceiling Effect Prevents High and Overdose

That said, Subutex still carries a higher potential for abuse than Suboxone, which contains the Naloxone safeguard.  And, to stop taking Subutex, a buprenorphine taper should be used instead of quitting cold turkey.  

Subutex FAQs

Subutex (buprenorphine) partially activates opioid receptors in the brain.

Because buprenorphine satisfies these opioid receptors, they don’t send signals triggering withdrawal symptoms or cravings.

Only partially activating the opioid receptors makes buprenorphine safer than full opioids like heroin, hydrocodone (Vicodin), oxycodone (OxyContin, Percocet), etc. and prevents the same “high”.

Suboxone and Subutex contain the same active ingredient, so switching between the medications is simple.  Most patients taking Subutex make the switch to Suboxone, whether it’s after a few days of detox or after pregnancy. There are not many situations where a doctor would agree to switch a patient from Suboxone to Subutex.

Subutex (buprenorphine) is used to treat Opioid Use Disorder but is not a first-choice medication.

Subutex is usually only used if a patient is:

  • Pregnant
  • Allergic to naloxone

Subutex (buprenorphine) is a safer medication than methadone, but methadone has more regulations around prescription and dispensing to help with safety issues.  That means both medications are safe treatment options when taken as directed. 

See also buprenorphine vs. methadone.

In response to COVID-19, restrictions were temporarily altered to allow online prescription of buprenorphine. (Though, states like Alabama have rolled back these measures).

However, there are limited situations where a doctor would prescribe Subutex — whether in person or online. Suboxone is the default medication choice because it is safer, which would be even more important in an online setting without having vitals or confirmed drug screen data.

Subutex Doctors Near Me

Subutex brand is no longer available, but buprenorphine-only medication is still used in specific circumstances. And, all patients can get relief from opioid withdrawal symptoms and stop  cravings with buprenorphine-based medications.

Subutex Doctors Near Illinois & Texas

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Symetria doctors follow rigorous sourcing guidelines and cite only trustworthy sources of information, including peer-reviewed journals, court records, academic organizations, highly regarded nonprofit organizations, government reports and their own expertise with decades in the field.

MENDELSON, J. (2003). Clinical and pharmacological evaluation of buprenorphine and naloxone combinations: why the 4:1 ratio for treatment? Drug and Alcohol Dependence, 70(2), S29–S37. https://doi.org/10.1016/s0376-8716(03)00057-7

‌Office. (2022). Buprenorphine: Drug Safety Communication. Retrieved August 10, 2022, from U.S. Food and Drug Administration website: https://www.fda.gov/safety/medical-product-safety-information/buprenorphine-drug-safety-communication-fda-warns-about-dental-problems-buprenorphine-medicines

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All content is for informational purposes only. No material on this site, whether from our doctors or the community, is a substitute for seeking personalized professional medical advice, diagnosis or treatment. Never disregard advice from a qualified healthcare professional or delay seeking advice because of something you read on this website.

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