Methadone is a low-potency opioid taken daily. It calms receptors in the brain that crave opioids. Because methadone is satisfying the opioid receptors, they don’t trigger withdrawal symptoms. With methadone occupying these receptors, opioids like heroin, morphine, or Oxycontin can’t produce the “high” feelings, if they are used. Without giving off the high, these drugs lose appeal.