Methadone (Dolophine®, Methadose®) is a proven, FDA-approved medication used to treat severe opioid addiction, including heroin, fentanyl or prescription painkillers like Oxycontin. Methadone is taken daily and only distributed by certified Opioid Treatment Programs (OTPs). Around 17% of opioid patients here choose Methadone. Methadone is a great option for chronic pain patients or those who haven’t had success with Suboxone or want extra accountability.